Insight on Efficient Biocompatible Magnetic Nanoparticles for Cancer Treatment using Magnetic Hyperthermia Technique

Abstract

Magnetic nanoparticles (NPs) bearing a superficial electrostatic charge can be dispersed in various polar media (usual solvents as water or DMSO), but also more complex ones such as Room Temperature Ionic Liquids (ILs) only constituted of ions. To obtain stable colloidal dispersions a well-adapted NP’s coating is necessary, chosen and controlled during the preparation. Here we review methods used in PHENIX laboratory - Paris - France to disperse charged NPs in water, DMSO and various ILs at various NP’s volume fractions (Φ) and temperature (T) by playing on the determined key parameters. They control two kinds of interactions of paramount importance, namely the NP/solvent interaction and the NP/NP interaction. The colloidal stability and the NP/NP interaction are probed by Small Angle Scattering of X-rays and/or neutrons. The parameters of NP/solvent interaction are obtained by the evolution of thermodiffusion with Φ and T by Forced Rayleigh Scattering, applying T-gradients and producing Φ-gradients on a 50 to 100 μm scale due to the Soret effect. An analysis of the under-field Soret anisotropy is presented. © 2023 R.P. Pant, Vidya Nand Singh, Komal Jain and Arvind Gautam.