Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Munk P.; Brinch C.; Møller F.D.; Petersen T.N.; Hendriksen R.S.; Seyfarth A.M.; Kjeldgaard J.S.; Svendsen C.A.; van Bunnik B.; Berglund F.; Bego A.; Power P.; Rees C.; Lambrinidis D.; Neilson E.H.J.; Gibb K.; Coventry K.; Collignon P.; Cassar S.; Allerberger F.; Begum A.; Hossain Z.Z.; Worrell C.; Vandenberg O.; Pieters I.; Victorien D.T.; Gutierrez A.D.S.; Soria F.; Grujić V.R.; Mazalica N.; Rahube T.O.; Tagliati C.A.; Rodrigues D.; Oliveira G.; de Souza L.C.R.; Ivanov I.; Juste B.I.; Oumar T.; Sopheak T.; Vuthy Y.; Ngandijo A.; Nzouankeu A.; Olivier Z.A.A.J.; Yost C.K.; Kumar P.; Brar S.K.; Tabo D.-A.; Adell A.D.; Paredes-Osses E.; Martinez M.C.; Sara C.O.; Ke C.; Zheng H.; Baisheng L.; Lau L.T.; Chung T.; Jiao X.; Yu Y.; JiaYong Z.; Morales J.F.B.; Valencia M.F.; Donado-Godoy P.; Coulibaly K.J.; Hrenovic J.; Jergović M.; Karpíšková R.; Deogratias Z.N.; Elsborg B.; Hansen L.T.; Jensen P.E.; Abouelnaga M.; Salem M.F.; Koolmeister M.; Legesse M.; Eguale T.; Heikinheimo A.; Le Guyader S.; Schaeffer J.; Villacis J.E.; Sanneh B.; Malania L.; Nitsche A.; Brinkmann A.; Schubert S.; Hesse S.; Berendonk T.U.; Saba C.K.S.; Mohammed J.; Feglo P.K.; Banu R.A.; Kotzamanidis C.; Lytras E.; Lickes S.A.; Kocsis B.; Solymosi N.; Thorsteinsdottir T.R.; Hatha A.M.; Ballal M.; Bangera S.R.; Fani F.; Alebouyeh M.; Morris D.; O’Connor L.; Cormican M.; Moran-Gilad J.; Battisti A.; Diaconu E.L.; Corno G.; Di Cesare A.; Alba P.; Hisatsune J.; Yu L.; Kuroda M.; Sugai M.; Kayama S.; Shakenova Z.; Kiiyukia C.; Ng’eno E.; Raka L.; Jamil K.; Fakhraldeen S.A.; Alaati T.; Bērziņš A.; Avsejenko J.; Kokina K.; Streikisa M.; Bartkevics V.; Matar G.M.; Daoud Z.; Pereckienė A.; Butrimaite-Ambrozeviciene C.; Penny C.; Bastaraud A.; Rasolofoarison T.; Collard J.-M.; Samison L.H.; Andrianarivelo M.R.; Banda D.L.; Amin A.; Rajandas H.; Parimannan S.; Spiteri D.; Haber M.V.; Santchurn S.J.; Vujacic A.; Djurovic D.; Bouchrif B.; Karraouan B.; Vubil D.C.; Pal P.; Schmitt H.; van Passel M.; Jeunen G.-J.; Gemmell N.; Chambers S.T.; Mendoza F.P.; Huete-Pιrez J.; Vilchez S.; Ahmed A.O.; Adisa I.R.; Odetokun I.A.; Fashae K.; Sørgaard A.-M.; Wester A.L.; Ryrfors P.; Holmstad R.; Mohsin M.; Hasan R.; Shakoor S.; Gustafson N.W.; Schill C.H.; Rojas M.L.Z.; Velasquez J.E.; Magtibay B.B.; Catangcatang K.; Sibulo R.; Yauce F.C.; Wasyl D.; Manaia C.; Rocha J.; Martins J.; Álvaro P.; Di Yoong Wen D.; Shin H.; Hur H.-G.; Yoon S.; Bosevska G.; Kochubovski M.; Cojocaru R.; Burduniuc O.; Hong P.-Y.; Perry M.R.; Gassama A.; Radosavljevic V.; Tay M.Y.F.; Zuniga-Montanez R.; Wuertz S.; Gavačová D.; Pastuchová K.; Truska P.; Trkov M.; Keddy K.; Esterhuyse K.; Song M.J.; Quintela-Baluja M.; Lopez M.G.; Cerdà-Cuéllar M.; Perera R.R.D.P.; Bandara N.K.B.K.R.G.W.; Premasiri H.I.; Pathirage S.; Charlemagne K.; Rutgersson C.; Norrgren L.; Örn S.; Boss R.; Van der Heijden T.; Hong Y.-P.; Kumburu H.H.; Mdegela R.H.; Hounmanou Y.M.G.; Chonsin K.; Suthienkul O.; Thamlikitkul V.; de Roda Husman A.M.; Bidjada B.; Njanpop-Lafourcade B.-M.; Nikiema-Pessinaba S.C.; Levent B.; Kurekci C.; Ejobi F.; Kalule J.B.; Thomsen J.; Obaidi O.; Jassim L.M.; Moore A.; Leonard A.; Graham D.W.; Bunce J.T.; Zhang L.; Gaze W.H.; Lefor B.; Capone D.; Sozzi E.; Brown J.; Meschke J.S.; Sobsey M.D.; Davis M.; Beck N.K.; Sukapanpatharam P.; Truong P.; Lilienthal R.; Kang S.; Wittum T.E.; Rigamonti N.; Baklayan P.; Van C.D.; Tran D.M.N.; Do Phuc N.; Kwenda G.; Larsson D.G.J.; Koopmans M.; Woolhouse M.; Aarestrup F.M.; Global Sewage Surveillance Consortium

Please use this identifier to cite or link to this item: http://10.10.120.238:8080/xmlui/handle/123456789/659

Title:	Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Authors:	Munk P. Brinch C. Møller F.D. Petersen T.N. Hendriksen R.S. Seyfarth A.M. Kjeldgaard J.S. Svendsen C.A. van Bunnik B. Berglund F. Bego A. Power P. Rees C. Lambrinidis D. Neilson E.H.J. Gibb K. Coventry K. Collignon P. Cassar S. Allerberger F. Begum A. Hossain Z.Z. Worrell C. Vandenberg O. Pieters I. Victorien D.T. Gutierrez A.D.S. Soria F. Grujić V.R. Mazalica N. Rahube T.O. Tagliati C.A. Rodrigues D. Oliveira G. de Souza L.C.R. Ivanov I. Juste B.I. Oumar T. Sopheak T. Vuthy Y. Ngandijo A. Nzouankeu A. Olivier Z.A.A.J. Yost C.K. Kumar P. Brar S.K. Tabo D.-A. Adell A.D. Paredes-Osses E. Martinez M.C. Sara C.O. Ke C. Zheng H. Baisheng L. Lau L.T. Chung T. Jiao X. Yu Y. JiaYong Z. Morales J.F.B. Valencia M.F. Donado-Godoy P. Coulibaly K.J. Hrenovic J. Jergović M. Karpíšková R. Deogratias Z.N. Elsborg B. Hansen L.T. Jensen P.E. Abouelnaga M. Salem M.F. Koolmeister M. Legesse M. Eguale T. Heikinheimo A. Le Guyader S. Schaeffer J. Villacis J.E. Sanneh B. Malania L. Nitsche A. Brinkmann A. Schubert S. Hesse S. Berendonk T.U. Saba C.K.S. Mohammed J. Feglo P.K. Banu R.A. Kotzamanidis C. Lytras E. Lickes S.A. Kocsis B. Solymosi N. Thorsteinsdottir T.R. Hatha A.M. Ballal M. Bangera S.R. Fani F. Alebouyeh M. Morris D. O’Connor L. Cormican M. Moran-Gilad J. Battisti A. Diaconu E.L. Corno G. Di Cesare A. Alba P. Hisatsune J. Yu L. Kuroda M. Sugai M. Kayama S. Shakenova Z. Kiiyukia C. Ng’eno E. Raka L. Jamil K. Fakhraldeen S.A. Alaati T. Bērziņš A. Avsejenko J. Kokina K. Streikisa M. Bartkevics V. Matar G.M. Daoud Z. Pereckienė A. Butrimaite-Ambrozeviciene C. Penny C. Bastaraud A. Rasolofoarison T. Collard J.-M. Samison L.H. Andrianarivelo M.R. Banda D.L. Amin A. Rajandas H. Parimannan S. Spiteri D. Haber M.V. Santchurn S.J. Vujacic A. Djurovic D. Bouchrif B. Karraouan B. Vubil D.C. Pal P. Schmitt H. van Passel M. Jeunen G.-J. Gemmell N. Chambers S.T. Mendoza F.P. Huete-Pιrez J. Vilchez S. Ahmed A.O. Adisa I.R. Odetokun I.A. Fashae K. Sørgaard A.-M. Wester A.L. Ryrfors P. Holmstad R. Mohsin M. Hasan R. Shakoor S. Gustafson N.W. Schill C.H. Rojas M.L.Z. Velasquez J.E. Magtibay B.B. Catangcatang K. Sibulo R. Yauce F.C. Wasyl D. Manaia C. Rocha J. Martins J. Álvaro P. Di Yoong Wen D. Shin H. Hur H.-G. Yoon S. Bosevska G. Kochubovski M. Cojocaru R. Burduniuc O. Hong P.-Y. Perry M.R. Gassama A. Radosavljevic V. Tay M.Y.F. Zuniga-Montanez R. Wuertz S. Gavačová D. Pastuchová K. Truska P. Trkov M. Keddy K. Esterhuyse K. Song M.J. Quintela-Baluja M. Lopez M.G. Cerdà-Cuéllar M. Perera R.R.D.P. Bandara N.K.B.K.R.G.W. Premasiri H.I. Pathirage S. Charlemagne K. Rutgersson C. Norrgren L. Örn S. Boss R. Van der Heijden T. Hong Y.-P. Kumburu H.H. Mdegela R.H. Hounmanou Y.M.G. Chonsin K. Suthienkul O. Thamlikitkul V. de Roda Husman A.M. Bidjada B. Njanpop-Lafourcade B.-M. Nikiema-Pessinaba S.C. Levent B. Kurekci C. Ejobi F. Kalule J.B. Thomsen J. Obaidi O. Jassim L.M. Moore A. Leonard A. Graham D.W. Bunce J.T. Zhang L. Gaze W.H. Lefor B. Capone D. Sozzi E. Brown J. Meschke J.S. Sobsey M.D. Davis M. Beck N.K. Sukapanpatharam P. Truong P. Lilienthal R. Kang S. Wittum T.E. Rigamonti N. Baklayan P. Van C.D. Tran D.M.N. Do Phuc N. Kwenda G. Larsson D.G.J. Koopmans M. Woolhouse M. Aarestrup F.M. Global Sewage Surveillance Consortium
Issue Date:	2022
Publisher:	Nature Research
Abstract:	Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention. © 2022, The Author(s).
URI:	https://dx.doi.org/10.1038/s41467-022-34312-7 http://localhost:8080/xmlui/handle/123456789/659
ISSN:	2041-1723
Appears in Collections:	Journal Article

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